Pfizer's COVID-19 immunity protection diminishes after 2 months المناعة تتضائل إلى 20% بعد 4 شهور حتى بعد جرعتين من لقاح فايزر

 

Pfizer's COVID-19 immunity protection diminishes after 2 months, and it can reach as low as 20% after 4 months: studies

• Two recent studies found that Pfizer's immunity protection diminishes rapidly a few months after a person has their second dose.

• بعد القيام بدراستين حديثتين وجد أن الحماية المناعية للقاح فايزر تتضائل سريعاً في أشهر قليلة للأفراد الذين حصلوا على الجرعة الثانية

• However, one study noted that the vaccine's protection against death and hospitalization still remained as high as 96%.

• بالرغم من ذلك فإن أحد الدراستين أشارت أن حماية اللقاح ضد الوفاة أو دخول المشفى مازالت مرتفة إلى 96% تقريبا

• The studies affirm Pfizer's earlier comments that its vaccines may not defend against COVID-19 infection as effectively over time.

• الدراسات أكدت تعقيبات فايزر السابقة أن لقاحهم ربما لا يحمي من عدوى كوفيد-19 بفاعلية مع مرور الوقت

COVID-19 immunity protection from two doses of the Pfizer vaccine starts dwindling after about two month, still, the shots remain effective in guarding against hospitalization and death, according to a pair of studies published in the New England Journal of Medicine on Wednesday.

The new findings affirm what Pfizer, Moderna, and the Centers for Disease Control and Prevention have indicated in recent weeks - that the vaccines' ability to protect the body from coronavirus infection may wane over time. Last month, the Food and Drug Administration authorized Pfizer booster shots for older or more vulnerable people.

In the first study, researchers from Qatar found that Pfizer's immunity protection drops to as low as 20% just four months after a person receives their second dose. They based their report on observations of infections among Qatar's over 900,000 vaccinated people.

The researchers found that Pfizer's protection against infection was "negligible" shortly after the first dose, but jumps to 36.8% three weeks later. When people receive their second dose, immunity protection increases to 77.5% after about a month.

But once that month is over, Pfizer's immunity effectiveness declines steadily, hovering at around 20% after the four-month mark, per the researchers.

"These findings suggest that a large proportion of the vaccinated population could lose its protection against infection in the coming months, perhaps increasing the potential for new epidemic waves," wrote the report.

Still, Pfizer's protection against hospitalization and death remained "robust" at 90% or higher for six months after the second dose, it said. The report also noted that its findings may not apply well to countries with older populations, since Qatar's population is relatively young with only 9% of its people being 50 or older.

The other study, conducted in Israel, looked at 4,868 healthcare workers. It reported that people have substantially decreased COVID-19 antibodies just six months after receiving their second dose of Pfizer's vaccine.

The drop is especially prominent among men, the elderly above 65, and those with weakened immune systems.

In comparison, vaccines for other conditions such as mumps, measles, and rubella only show small decreases of about 5% to 10% each year in neutralizing antibody levels, wrote the researchers.

They also noted that they observed higher antibody counts in obese participants who have a body mass index of 30 or above.

"Yet, it is still unclear whether vaccinated obese persons are at higher or lower risk for breakthrough infection and whether the relatively high humoral response to the vaccine is protective," the report stated.

خلاصة ما سبق وكل ما يدور منذ عامين أن اللقاح ليس فعالاً طول العمر ولا حتى لسنوات بل وجد أنه حتى من تعاطى الجرعة المحفزة كما يسمونها أو المنشطة أيضاً تتلاشى فاعليتها بعد فترة آي أن كل من أخذ الجرعتين بعد 6 أشهر من الجرعة الثانية وقد يكون بعد 120 يوم فقط تقل المناعة لديه وسيستمر هذا الأمر والسؤال هل سيصبح مثل لقاح الأنفلونزا (الرباعي الآن) أم ماذا؟ كذلك بدأت تجارب كبسولات تعطى لمن أصيب بالمرض في الأيام الأولى (لا يزيد عن 5 أيام) وهي تمنع أنتشار وتكاثر المرض لديه عن طريق تبديل معين يؤدي إلى إعطاء إشارات خاطئة للفايرس عند تكوين مزيد منه فلا يتكاثر ومازال الأمر تحت البحث (ملحوظة أخيرة كل ما أكتبه هنا هو من مواقع طبية ونشرات ومجلات يتم نشرها أو مرئيات ومناقشات أستمع إليها) يعني من الآخر أنا لست طبيباً ولكني أحب القراءة

مع أقتراب موعد مصل (لقاح الأنفلونزا) قد تم تعديل وترقية اللقاح ليصبح رباعي وهذه معلومات أولية عن اللقاح ولكن للأسف لأمريكا ولكن المعلومات تفيد الجميع

 

Quadrivalent Influenza Vaccine

Brand names: AFLURIA Quadrivalent, Fluarix Quadrivalent, FluLaval Quadrivalent, Flucelvax Quadrivalent and Fluzone Quadrivalent, FluMist Quadrivalent

ما هو لقاح الانفلونزا الرباعي؟

تم تصميم لقاح الإنفلونزا رباعي التكافؤ للحماية من أربعة فيروسات مختلفة للإنفلونزا ، بما في ذلك اثنان من فيروسات الإنفلونزا النوعية إيه واثنان من فيروسات الإنفلونزا النوعية بي.

What is quadrivalent flu vaccine?

A quadrivalent influenza (flu) vaccine is designed to protect against four different flu viruses, including two influenza A viruses and two influenza B viruses.

Why was quadrivalent flu vaccine developed?

لماذا تم تطوير لقاح الأنفلونزا الرباعي

For many years, flu vaccines were designed to protect against three different flu viruses: an influenza A(H1N1) virus, an influenza A(H3N2) virus and one influenza B virus, even though there are two different lineages of B viruses that circulate during most seasons. Adding a B virus from the second lineage was done to give broader protection against circulating flu viruses.
Who can get quadrivalent flu vaccine?
من يمكن أن يأخذ لقاح الأنفلونزا رباعي التكافؤ؟

All flu vaccines in the United States for the 2021-2022 season are quadrivalent vaccines. Different vaccines are approved for different age groups. There is a quadrivalent flu shot that can be given to children as young as 6 months old. Flucelvax Quadrivalent is now approved for people 2 years and older. More information on approved flu vaccines for the 2020-2021 flu season, and age indications for each vaccine are available in CDC’s

الأشخاص العاديين من سن عامين إلى 49 سنة والمرأة غير الحامل يمكن أن تأخذ المصل بخاخ الأنف ولكن الأشخاص الذين يعانون من حالات مرضية معينة يجب أن لا يتعاطو اللقاح بخاخ الأنف

The quadrivalent nasal spray vaccine is approved for use in non-pregnant individuals, 2 years through 49 years old. People with certain medical conditions should not receive the nasal spray influenza vaccine.
Who shouldn’t get quadrivalent flu vaccine?
من الذي يجب أن لا يأخذ لقاح الأنفلونزا ؟


Different influenza (flu) vaccines are approved for use in people in different age groups. In addition, some vaccines are not recommended for certain groups of people. Factors that can determine a person’s suitability for vaccination, or vaccination with a particular vaccine, include a person’s age, health (current and past) and any allergies to flu vaccine or its components.




People who SHOULD NOT get a flu shot include:
Children younger than 6 months of age are too young to get a flu shot.
People with severe, life-threatening allergies to any ingredient in a flu vaccine (other than egg proteins) should not get that vaccine. This might include gelatin, antibiotics, or other ingredients.
People who have had a severe allergic reaction to a dose of influenza vaccine should not get that flu vaccine again and might not be able to receive other influenza vaccines. If you have had a severe allergic reaction to an influenza vaccine in the past, it is important to talk with your health care provider to help determine whether vaccination is appropriate for you.
Are any of the available flu vaccines recommended over the others?
هل يوجد لقاح يوصى به خير من أخر؟ بالطبع لا ولكن يوجد لقاح لا يصلح لأشخاص معينين بسبب حالات حساسية أو أمراض لديهم فيأخذ بديل مثل من لديهم حساسية من البيض


For the 2021-2022 flu season, the Advisory Committee on Immunization Practices (ACIP) recommends annual influenza (flu) vaccination for everyone 6 months and older with any licensed, influenza vaccine that is appropriate for the recipient’s age and health status, including inactivated influenza vaccine (IIV4), recombinant influenza vaccine (RIV4), or live attenuated nasal spray influenza vaccine (LAIV4) with no preference expressed for any one vaccine over another.

There are many vaccine options to choose from, but the most important thing is for all people 6 months and older to get a flu vaccine every year. If you have questions about which vaccine is best for you, talk to your doctor or other health care professional.
Are quadrivalent flu vaccines safe?
هل لقاح الأنفلونزا الرباعي آمن؟
بالتأكيد هو آمن مع الغالبية ولا يسبب الأنفلونزا لأن الفيروسات المستخدمه فيه ميته أو ضعيفة أو مصنعة بطريقة لا تتضمن فيروس الأنفلونزا

Yes. Flu vaccines that protect against four flu viruses have a safety profile similar to seasonal flu vaccines made to protect against three viruses, with similar—mostly mild—side effects. Like all seasonal flu vaccines, vaccines that protect against four flu viruses are monitored annually for their safety and effectiveness.

Quadrivalent vaccine cannot cause flu illness because they contain ‘inactivated’ (killed) virus, attenuated (weakened) virus, or are made using recombinant methods that don’t use flu virus in the manufacturing process.

Special Consideration Regarding Egg Allergy
من لديهم حساسية من البيض لابد أن يؤخذ ذلك في الأعتبار ويوجد أمصال تصلح لهم ولا تسبب آي حساسية


People with egg allergies can receive any licensed, recommended age-appropriate influenza vaccine (IIV4, RIV4, or LAIV4) that is otherwise appropriate. People who have a history of severe egg allergy (those who have had any symptom other than hives after exposure to egg) should be vaccinated in a medical setting, supervised by a health care provider who is able to recognize and manage severe allergic reactions. Two completely egg-free (ovalbumin-free) flu vaccine options are available: quadrivalent recombinant vaccine and quadrivalent cell-based vaccine.

https://www.cdc.gov/flu/prevent/quadrivalent.htm

https://www.cdc.gov/flu/season/faq-flu-season-2021-2022.htm

عندما تقرأ تتعلم وتفهم وعندما تتعلم وتفهم يمكن أن تتكلم

When you read you learn and understand, and when you learn and understand YOU CAN TALK

شرح فيديو بسيط الأول إذا تعتقد أو تعلم أنك مصاب بكوفيد 19 ؟ الثاني إذا علمت أنك مصاب بكوفيد 19 ولا يوجد أعراض؟ الثالث الفرق بين الحجر الصحي والعزل؟

 

الله المستعان ، الجرعة المحفزة أو المنشطة أو الجرعة الثالثة! آي كان الأسم أصبحت ضرورة ثم الآن التركيز على فايزر جرعة تنشيطية أو مودرنا نصف جرعة! ولا كلام على إسترازنكا

مع قدوم فصل الخريف والشتاء يتسابق العالم في محاولات مواجهة الأنفلونزا الموسمية التي يؤخذ لها لقاح والجرعة المنشطة أو الثالثة

(وليست الأخيرة) لكوفيد 19 ونحن في الموجة (التحور الرابع مو)

اللافت للنظر أن الجميع يأخذ إسرائيل التي تعتبر من أفضل دول العالم في موضوع اللقاح للمواطنين نموذجا يحتذى به حيث التجارب والإرشادات والملاحظات تخرج منها أولاً بل أمريكا تأخذ بقولهم!! والله المستعان ، ثم الملاحظة الثانية أنه تم الأعتراف رسمياً بأن اللقاح تقل فاعليته وقد تنعدم بعد ستة أشهر ، الملاحظة الثالثة هي أن الجرعة الثالثة أو ما يسمى بالتنشيطية تأخذ بالإعتبار أخطاء ونتائج العامين الماضيين ، فالجميع يحاول أن تكون الجرعة من فايزر كاملة أو نصف جرعة من موديرنا (لأن الأعراض للنصف الجرعة أقل) والأبتعاد عن أن تكون الجرعة المنشطة من أسترازنكا والملاحظة الأخيرة هي الجميع يخزن الللقاحات طبعا الدول الغنية ولا يلتفت إلى الدول الفقيرة! والله المستعان كذلك لا كلام على لقاحات الصين وغيرها من اللقاحات التي تكاد تكون معروفة إلا في

https://www.dailymail.co.uk/news/article-9988825/Booster-vaccines-50s.html بعض الدول العربية هذا من مقال في الديلي ميل البريطانية

Government's vaccine advisory panel has recommended third doses be dished out to some 30million people
Plans approved on the back of real-world data in Israel and elsewhere suggesting immunity wanes in months
Britons who are eligible will be given Pfizer's vaccine or a half-dose of the Moderna vaccine

The Government’s vaccine advisory panel recommended a third dose for roughly 30million people aged 50 and over who received their second injection at least six months ago.



Members of the Joint Committee on Vaccination and Immunisation (JCVI) approved the plans on the back of growing real-world data in Israel and elsewhere, as well as a major British study, which suggested vaccine-induced immunity wanes within months.




Britons who are eligible will be given the Pfizer vaccine in the first instance, no matter which jab they were originally immunised with. When there are supply constraints, the Moderna vaccine will be offered as a booster in the form of a half dose.

Officials said there was more evidence that the mRNA vaccines were safe and effective when given as a third dose, which is why they are not recommending AstraZeneca's.

Moderna's is being recommended as a half dose because the lower dosage is associated with fewer side effects and still produces a strong immune response, the JCVI said.

People who are invited for their booster Covid vaccine will be able to get their flu jab at the same time, in the opposite arm.














Professor Wei Shen Lim, of the Joint Committee on Vaccination and Immunisation, said the recommendation of at least a six-month gap between the second jab and a booster shot was an attempt to find an immunity 'sweet spot'.


'We want to suggest a six-month limit as a lower limit because we don’t want people to feel they need to rush to have this booster dose,' he told a Downing Street press conference.

'Getting a booster dose too early might mean getting a dose when they don’t actually need to have vaccination because they still have a high level of protection.

'And, as we have seen with the first and second dose, it may be that a longer interval to the third booster dose may actually be beneficial in the longer term.

'On the other hand, we don’t want to wait too long before offering a booster dose, so trying to find a sweet spot between going too soon and going too late we are suggesting that the booster dose is given no earlier than six months after the second dose.'




Professor Lim said it was preferable for people to get an mRNA vaccine as a booster — such as those made by Pfizer and Moderna — because there was more evidence compared to the AstraZeneca jabs that these are safe and effective.

He told the briefing: 'The AstraZeneca vaccine obviously is a very good vaccine for its primary cause.

'We’ve seen data that suggests that the mRNA vaccines given, whatever the primary cause for the vaccination is, gives a very good boost.

اللهم صل وسلم وبارك على سيدنا ونبينا محمد وآله وصحبه وسلم

 اللهم شفع نبينا محمد صلى الله  عليه وسلم فينا يوم لا ينفع مال ولا بنون

هذه السلسلة من منظمة الصحة العالمية يوجد بها نشرات قيمة مختصرة عن كوفيد 19 وغيرها والتحورات واللقاحات

سلسلة العلم في خمس دقائق 

كل فترة يظهر شئ جديد فايزر مشاكل بالقلب استرازنكا تجلطات بالدم موديرنا عضلة القلب والآن في اليابان إيقاف مودرنا أحترازياً لوفاة شخصين بعد الجرعة الثانية!

 

Two die in Japan after shots from

 suspended Moderna vaccines

 - Japan govt

TOKYO, Aug 28 (Reuters) - Two people died after receiving Moderna COVID-19 vaccine shots that were among lots later suspended following the discovery of contaminants, Japan's health ministry said on Saturday.

The men in their 30s died this month within days of receiving their second Moderna doses, the ministry said in a release. Each had a shot from one of three manufacturing lots suspended on Thursday. The cause of the deaths is still being investigated.

Japan halted the use of 1.63 million Moderna doses https://www.reuters.com/world/asia-pacific/japan-withdraws-16-mln-moderna-covid-19-vaccine-doses-over-contamination-nikkei-2021-08-25 shipped to 863 vaccination centres nationwide, more than a week after the domestic distributor, Takeda Pharmaceutical, received reports of contaminants in some vials.

The government and Moderna had said no safety or efficacy issues had been identified and the suspension was just a precaution.


The contaminant is believed to be metallic particles, Japanese public broadcaster NHK reported, citing health ministry sources.